方亮

姓名：方亮

性别：男

籍贯：吉林

联系电话：02443520511

E-Mail：fangliangspu@aliyun.com,fangliangsp@yahoo.com.cn

个人主页：

职称/职务：教授/博士生导师/金沙6165总站线路检测院长

通讯地址：辽宁省本溪高新技术开发区华佗大街26号

邮政编码：117004

学习/工作经历：

1987年7月,沈阳金沙6165总站线路检测药学系药物制剂专业毕业

1987年8月～1988年12月，吉林省医药工业研究所任助理工程师

1989年1月～1992年7月，吉林省延边医药管理局工业科任科员

1992年8月～1994年2月，吉林省延边中药厂任副厂长，工程师

1994年3月～2000年3月，延边大学金沙6165总站线路检测药剂学教研室任讲师，副教授

1999年7月，在延边大学金沙6165总站线路检测获得理学硕士学位

1999年4月～2000年3月，以日中笹川医学研究者制度第22期生,日本城西大学药学部

2003年3月，在日本城西大学药学部获得药学博士学位

2003年4月～2004年3月，日本城西大学药学部博士后

2004年4月～现在，金沙6165总站线路检测药剂教研室任教授

兼职情况：

世界中医药联合会经皮给药专业委员会副会长

Asian Journal of Pharmaceutical Sciences编委

国家食品药品监督管理局新药审评专家

国家自然科学基金函审评议专家

教育部留学回国人员科研启动基金评审专家

辽宁省委省政府决策咨询委员会中青年专家

重庆市化学制药工程技术中心技术委员会成员

金沙6165总站线路检测学位评定委员会药剂学分科委员会主席

教育部高等学校药学类专业教学指导委员会（大）药学分委会副主任委员

中国药学会24届青年工作委员会委员

长白山生物资源与功能分子教育部重点实验室（延边大学）学术委员会委员

透皮给药系统山西省重点实验室学术委员会委员

《中国药剂学杂志》副主编

《中国合理用药探索》编委

《金沙6165总站线路检测学报》常务编委

科研/获奖情况：

主持了国家自然科学基金项目“两亲经皮促透剂薄荷醇修饰物酯的结构优化及促透机制的研究”（批准号：81173007）,“l-香芹醇酯类衍生物经皮促透作用的可逆性及其机理研究”（批准号：30973654）和“分子间相互作用对经皮给药贴剂的释药特性及生物粘附性的影响机制及分子基础”（批准号：81773665）三项；高等学校博士学科点专项基金项目“l-香芹醇酯类衍生物经皮促透作用的可逆性及其机理研究”（批准号：20092134110002）一项；国家“十一五重大新药创制”大平台子项目“左旋氨氯地平贴剂的开发”（新药2009ZX09301—012）一项；国家“十一五重大新药创制”辽宁省国家创新药物孵化（本溪）基地建设子项目“阿扎司琼贴剂的开发”（新药2010ZX09401—304）一项；参与国家科技部“973”重大科学研究计划项目“纳米技术改善难溶性药物功效的应用基础研究”（2009CB903302）一项。国际学术会议大会报告6次，授权专利14项。

2011年被评为金沙6165总站线路检测教学名师；2014年入选辽宁省特聘教授；2015年被评为辽宁省普通高校教学名师；2016年入选山东省泰山产业领军人才；2018年入选国务院特殊津贴专家。

教学/指导研究生情况：

讲授本科生课程：药剂学、生物药剂学、药物动力学

指导博士研究生19名（其中毕业16名）、硕士研究生56名（其中毕业39名）

发表论文/出版著作：

发表论文：在国内外学术期刊发表论文90多篇，其中SCI收载70多篇。

编写著作：

《药剂学学习指导书》（主编）中国医药科技出版社，2011年

《经皮给药新剂型》（副主编）人民卫生出版社，2006年

《药用高分子材料学》（副主编）中国医药科技出版社，2009年

《药物制剂注解》（副主编）人民卫生出版社，2010年

《药剂学》（第二版）（编者）中国医药科技出版社，2010年

《药剂学》（第七版）（编者）人民卫生出版社，2011年

《中华医学百科全书药剂学分卷》（编者），正在编写。

发表的SCI论文：

[1] Zhao H, Liu C, Yang D, Wan X, Shang R, Quan P, Fang L. Molecular mechanism of ion-pair releasing from acrylic pressure sensitive adhesive containing carboxyl group: Roles of doubly ionic hydrogen bond in the controlled release process of bisoprolol ion-pair. J Control Release. 2018 Nov 10;289:146-157.

[2]Yang D, Wan X, Quan P, Liu C, Fang L. The role of carboxyl group of pressure sensitive adhesive in controlled release of propranolol in transdermal patch: Quantitative determination of ionic interaction and molecular mechanism characterization. Eur J Pharm Sci. 2018 Mar 30;115:330-338.

[3]Wang W, Liu C, Luo Z, Wan X, Fang L. Investigation of molecular mobility of pressure-sensitive-adhesive in oxybutynin patch in vitro and in vivo: Effect of sorbitan monooleate on drug release and patch mechanical property. Eur J Pharm Sci. 2018 Sep 15;122:116-124.

[4]Shen M, Liu C, Wan X, Farah N, Fang L. Development of a daphnetin transdermal patch using chemical enhancer strategy: insights of the enhancement effect of Transcutol P and the assessment of pharmacodynamics. Drug Dev Ind Pharm. 2018 Oct;44(10):1642-1649.

[5]Shang R, Liu C, Quan P, Zhao H, Fang L. Effect of drug-ion exchange resin complex in betahistine hydrochloride orodispersible film on sustained release, taste masking and hygroscopicity reduction. Int J Pharm. 2018 Jul 10;545(1-2):163-169.

[6]Luo Z, Wan X, Liu C, Fang L. Mechanistic insights of the controlled release properties of amide adhesive and hydroxyl adhesive. Eur J Pharm Sci. 2018 Jul 1;119:13-21.

[7]Li Q, Wan X, Liu C, Fang L. Investigating the role of ion-pair strategy in regulating nicotine release from patch: Mechanistic insights based on intermolecular interaction and mobility of pressure sensitive adhesive. Eur J Pharm Sci. 2018 Jul 1;119:102-111.

[8]Zhao H, Liu C, Quan P, Wan X, Shen M, Fang L. Mechanism study on ion-pair complexes controlling skin permeability: Effect of ion-pair dissociation in the viable epidermis on transdermal permeation of bisoprolol. Int J Pharm. 2017 Oct 30;532(1):29-36.

[9]Wang W, Song T, Wan X, Liu C, Zhao H, Fang L. Investigate the control release effect of ion-pair in the development of escitalopram transdermal patch using FT-IR spectroscopy, molecular modeling and thermal analysis. Int J Pharm. 2017 Aug 30;529(1-2):391-400.

[10]Liu X, Quan P, Li S, Liu C, Zhao Y, Zhao Y, Fang L. Time dependence of the enhancement effect of chemical enhancers: Molecular mechanisms of enhancing kinetics.J Control Release. 2017 Feb 28;248:33-44.

[11]Liu X, Liu M, Liu C, Quan P, Zhao Y, Fang L. An insight into the molecular mechanism of the temporary enhancement effect of isopulegol decanoate on the skin. Int J Pharm. 2017 Aug 30;529(1-2):161-167.

[12]Liu C, Quan P, Li S, Zhao Y, Fang L. A systemic evaluation of drug in acrylic pressure sensitive adhesive patch in vitro and in vivo: The roles of intermolecular interaction and adhesive mobility variation in drug controlled release. J Control Release. 2017 Apr 28;252:83-94.

[13]Li N, Quan P, Wan X, Liu C, Liu X, Fang L. Mechanistic insights of the enhancement effect of sorbitan monooleate on olanzapine transdermal patch both in release and percutaneous absorption processes.Eur J Pharm Sci. 2017 Sep 30;107:138-147.

[14]Zhao C, Quan P, Liu C, Li Q, Fang L.Effect of isopropyl myristate on the viscoelasticity and drug release of a drug-in-adhesive transdermal patch containing blonanserin. Acta Pharm Sin B. 2016 Nov;6(6):623-628.

[15]Weng W, Quan P, Liu C, Zhao H, Fang L. Design of a Drug-in-Adhesive Transdermal Patch for Risperidone: Effect of Drug-Additive Interactions on the Crystallization Inhibition and In Vitro/In Vivo Correlation Study. J Pharm Sci. 2016 Oct;105(10):3153-3161.

[16]Song W, Quan P, Li S, Liu C, Lv S, Zhao Y, Fang L. Probing the role of chemical enhancers in facilitating drug release from patches: Mechanistic insights based on FT-IR spectroscopy, molecular modeling and thermal analysis. J Control Release. 2016 Apr 10;227:13-22.

[17]Song T, Quan P, Xiang R, Fang L. Regulating the Skin Permeation Rate of Escitalopram by Ion-pair Formation with Organic Acids. AAPS PharmSciTech. 2016 Dec;17(6):1267-1273.

[18]Lv S, Quan P, Wang W, Fang L.Two steps modification for improvement of cyclobenzaprine transdermal delivery: releasing from patch and penetrating through skin.Drug Dev Ind Pharm. 2016 Dec;42(12):2070-2077.

[19]Liu N, Zhang Y, Cun D, Quan P, Fang L.Effect of backing films on the transdermal delivery of donepezil from patches. AAPS PharmSciTech. 2014 Dec;15(6):1569-73.

[20]Liu C, Hui M, Quan P, Fang L.Drug in adhesive patch of palonosetron: Effect of pressure sensitive adhesive on drug skin permeation and in vitro-in vivo correlation.Int J Pharm. 2016 Sep 25;511(2):1088-97.

[21]Liu C, Quan P, Fang L.Effect of drug physicochemical properties on drug release and their relationship with drug skin permeation behaviors in hydroxyl pressure sensitive adhesive.Eur J Pharm Sci. 2016 Oct 10;93:437-46.

[22]Hui M, Quan P, Yang Y, Fang L The effect of ion-pair formation combined with penetration enhancers on the skin permeation of loxoprofen.Drug Deliv. 2016 Jun;23(5):1550-7.

[23]Cui H, Quan P, Zhou Z, Fang L. Development of a drug-in-adhesive patch combining ion pair and chemical enhancer strategy for transdermal delivery of zaltoprofen: pharmacokinetic, pharmacodynamic and in vitro/in vivo correlation evaluation.Drug Deliv. 2016 Nov;23(9):3461-3470.

[24]Zhao Y, Quan P, Fang L. Preparation of an oral thin film containing meclizine hydrochloride: In vitro and in vivo evaluation. Int J Pharm. 2015 Dec 30;496(2):314-22.

[25]Song W, Cun D, Quan P, Liu N, Chen Y, Cui H, Xiang R, Fang L. Dual-directional regulation of drug permeating amount by combining the technique of ion-pair complexation with chemical enhancers for the synchronous permeation of indapamide and bisoprolol in their compound patch through rabbit skin.Eur J Pharm Biopharm. 2015 Apr;91:59-65.

[26]Li Y, Dong C, Cun D, Liu J, Xiang R, Fang L. Lamellar Liquid Crystal Improves the Skin Retention of 3-O-Ethyl-Ascorbic Acid and Potassium 4-Methoxysalicylate In Vitro and In Vivo for Topical Preparation. AAPS PharmSciTech. 2016 Jun;17(3):767-77.

[27]Liu N, Song W, Song T, Fang L. Design and Evaluation of a Novel Felbinac Transdermal Patch: Combining Ion-Pair and Chemical Enhancer Strategy. AAPS PharmSciTech. 2016 Apr;17(2):262-71.

[28]Liu C, Fang L.Drug in Adhesive Patch of Zolmitriptan: Formulation and In vitro /In vivo Correlation. AAPS PharmSciTech. 2015 Dec;16(6):1245-53.

[29]Dong L, Liu C, Cun D, Fang L. The effect of rheological behavior and microstructure of the emulgels on the release and permeation profiles of Terpinen-4-ol. Eur J Pharm Sci. 2015 Oct 12;78:140-50.

[30]Cui H, Quan P, Zhao H, Wen X, Song W, Xiao Y, Zhao Y, Fang L. Mechanism of Ion-Pair Strategy in Modulating Skin Permeability of Zaltoprofen: Insight from Molecular-Level Resolution Based on Molecular Modeling and Confocal Laser Scanning Microscopy.J Pharm Sci. 2015 Oct;104(10):3395-403.

[31]Che QE, Quan P, Mu M, Zhang X, Zhao H, Zhang Y, You S, Xiao Y, Fang L.Enantioselective skin permeation of ibuprofen enantiomers: mechanistic insights from ATR-FTIR and CLSM studies based on synthetic enantiomers as naphthalimide fluorescent probes.Expert Opin Drug Deliv. 2014 Oct;11(10):1513-23.

[32]Chen Y, Quan P, Liu X, Guo W, Song W, Cun D, Wang Z, Fang L. Enhancement of skin permeation of flurbiprofen via its transdermal patches using isopulegol decanoate (ISO-C10) as an absorption enhancer: pharmacokinetic and pharmacodynamic evaluation. J Pharm Pharmacol. 2015 Sep;67(9):1232-9.

[33]Shang L, Cun D, Xi H, Fang L. An explanation for the difference in the percutaneous penetration behavior of tamsulosin induced by two different O-acylmenthol derivatives. AAPS PharmSciTech. 2014 Aug;15(4):803-9.

[34]Li W, Quan P, Zhang Y, Cheng J, Liu J, Cun D, Xiang R, Fang L. Influence of drug physicochemical properties on absorption of water insoluble drug nanosuspensions.Int J Pharm. 2014 Jan 2;460(1-2):13-23.

[35] Liu N, Zhang Y, Cun D, Quan P, Fang L. Effect of backing films on the transdermal delivery of donepezil from patches. AAPS PharmSciTech. 2014 Dec;15(6):1569-73.

[36] Chen Y, Cun D, Quan P, Liu X, Guo W, Peng L, Fang L.Saturated long-chain esters of isopulegol as novel permeation enhancers for transdermal drug delivery.Pharm Res. 2014 Aug;31(8):1907-18.

[37] Xi H, Cun D, Xiang R, Guan Y, Zhang Y, Li Y, Fang L. Intra-articular drug delivery from an optimized topical patch containing teriflunomide and lornoxicam for rheumatoid arthritis treatment: does the topical patch really enhance a local treatment? J Control Release. 2013 Jul 10;169(1-2):73-81.

[38]Wang M, Xi H, Cun D, Chen Y, Xu Y, Fang L.l-Carvyl esters as penetration enhancers for the transdermal delivery of 5-fluorouracil. AAPS PharmSciTech. 2013 Jun;14(2):669-74.

[39]Chen Y, Wang J, Cun D, Wang M, Jiang J, Xi H, Cui H, Xu Y, Cheng M, Fang L. Effect of unsaturated menthol analogues on the in vitro penetration of 5-fluorouracil through rat skin.Int J Pharm. 2013 Feb 25;443(1-2):120-7.

[40]Xi HL, Cun D, Wang Z, Shang L, Song W, Mu L, Fang L. Effect of the stability of hydrogen-bonded ion pairs with organic amines on transdermal penetration of teriflunomide. Int J Pharm, 2012, 436:857-861.

[41]HL, Xi, L Fang. The relationship between hydrogen-bonded ion-pair stability and transdermal penetration of lornoxicam with organic amines. Eur J Pharm Sci,2012,47:325-330. (通讯作者)

[42]NX, Zhao, DM Cun, W Li, L Sun, HL Xi, L Li, L Fang. In vitro percutaneous absorption enhancement of granisetron by chemical penetration enhancers. Drug Deve Ind Pharm, accepted. (DOI: 10.3109/03639045.2012.665924) (通讯作者)

[43] N Zeng, QY Hu, ZY Liu, XL Gao, RK Hu, QX Song, GZGu, HM Xia, L Yao, ZQ Pang, XG Jiang, J Chen, L Fang. Preparation and characterization of paclitaxel-loaded DSPE-PEG-liquidcrystalline nanoparticles (LCNPs) for improved bioavailability. Int J Pharm, 2012, 424:58-56. (通讯作者)

[44]J Liu, ZY Wang, C Liu, HL Xi, CM Li, Y Chen, L Sun, L Mu, L Fang. Silicone adhesive, a better matrix for tolterodine patches—a research based on in vitro/in vivo studies. Drug Deve Ind Pharm, accepted. (DOI: 10.3109/03639045.2011.637049) (通讯作者)

[45]ZY Wen; ZQ Yan; K Hu; R He; ZQ Pang; LR Guo; Y Qian; XG Jiang; L Fang. Brain targeting and toxicity study of odorranalectin-conjugated nanoparticles following intranasal administration. Drug Delivery, 2011, 18 (3): 555-561. (通讯作者)

[46]W Sun, W Tian, Y Zhang, J He, S Mao, L Fang. Effect of novel stabilizers—cationic polymers on the particle size and physical stability of poorly soluble drug nanocrystals. Nanoedicine, accepted. (通讯作者)

[47] CM Li, C Liu, J Liu, L Fang. Correlation Between Rheological Properties, In Vitro Release, and Percutaneous Permeation of Tetrahydropalmatine. AAPS Pharm Sci Tech, 2011, 12 (3): 1002-1010. (通讯作者)

[48]W Sun, SR Mao, Y Shi, LC Li, L Fang. Nanonization of itraconazole by high pressure homogenization: Stabilizer optimization and effect of particle size on oral absorption. J Pharm Sci, 2011, 100(8):3365-3373.

[49]ZY Wen; ZQ Yan; K Hu; ZQ Pang; XF Cheng; LR Guo; QZ Zhang; R Lai; XG Jiang; L Fang. Odorranalectin-conjugated nanoparticles: Preparation, brain delivery and pharmacodynamic study on parkinson‘s disease following intranasal administration. J Control Release, 2011, (15)：131-138. (通讯作者)

[50] W Li, YG Yang, YS Tian, XL Xu, YChen, L Mu, YQ Zhang, L Fang. Preparation and in vitro/in vivo evaluation of revaprazan hydrochloride nanosuspension. Int J Pharm, 2011, 408:157-162. (通讯作者)

[51]LG Zhao, L Fang, YN Xu, N Zheng, ZG He. Effect of (E)-2-isopropyl-5- methylcyclohexyl octadec-9-enoate on transdermal delivery of aconitum alkaloids. Drug Deve Ind Pharm, 2011;37(3):290-299. (通讯作者)

[52]L Li, L Fang, XL Xu, Y Liu, YH Sun, ZG He. The Transdermal Patches for Site-Specific Delivery of Letrozole: A New Option for Breast Cancer Therapy. AAPS Pharm Sci Tech, 2010, 11(3):1054-7. (通讯作者)

[53]X Ma, L Fang, JP Guo, NX Zhao, ZG He. Effect of counter-ions and penetration enhancers on the skin permeation of flurbiprofen. J Pharm Sci, 2010, 99(4):1826-1837. (通讯作者)

[54]HL Xi, YG Yang, DM Zhao, L Fang, L Sun, LW Mu, J Liu, NX Zhao, YY Zhao, N Zheng, ZG He. Transdermal patches for site-specific delivery of anastrozole: In vitro and local tissue disposition evaluation. Int J Pharm, 2010, 391:73–78. (通讯作者)

[55]L Li, L Fang, XL Xu, Y Liu, YH Sun, ZG He. Formulation and biopharmaceutical evaluation of a transdermal patch containing letrozole. Biopharmaceutics & Drug Disposition, 2010, 31: 138-149. (通讯作者)

[56] Y Liu, SD Yoo, L Fang, X Jin, L Li, TF Li. . Ion-pair LC-UV method for the determination of boanmycin in moude plasma and its application to a pharmacokinetic atudy. Chromatographia, 2010, 72:357-359.

[57] YH Suna, L Fang, M Zhua, W Li , P Meng, L Li, ZG He. A drug-in-adhesive transdermal patch for S-amlodipine free base: In vitro and in vivo characterization. Int J Pharm, 2009, 382 : 165–171 (通讯作者)

[58]Z Tan, JY Zhang, J Wu, L Fang, ZG He. The Enhancing Effect of Ionpairing on the Skin Permeation of Glipizide. AAPS Pharm Sci Tech, 2009, 10(3):967-976. (通讯作者)

[59]Y Liu, SD Yoo, L Fang, X Jin, L Li, YJ Ren, CS Yao, TF Li. Determiniation of boanmycinin pharmaceiytical preparations by a simple and rapid ion-pair LC method. Chromatographia, 2009, 70:643-646.

[60]LG Zhao, Y Li, L Fang, YN Xu, ZG He. Transdermal delivery of tolterodine by O-acylmenthol: In vitro/in vivo correlation. Int J Pharm, 2009, 374: 73–81. (通讯作者)

[61]LG Zhao, Y Li, L Fang, YN Xu, ZG He. Effect of O-acylmenthol and salt formation on the skin permeation of diclofenac acid. Drug Dev Ind Pharm, 2009, 35: 814–826 (通讯作者)

[62]ZY Wen, L Fang, ZG He. Effect of chemical enhancers on percutaneous absorption of daphnetin in isopropyl myristate vehicle across rat skin in vitro. Drug Delivery, 2009, 16: 214-223. (通讯作者)

[63]JY Zhang, L Fang, Zhe Tan, Jian Wu, and Zhong-Gui He. Influence of ion-pairing and chemical enhancers on the transdermal delivery of meloxicam. Drug Dev Ind Pharm, 2009; 35: 663–670. (通讯作者)

[64]CS Ren, L Fang, L Ling, Q Wang, S Liu, LG Zhao, ZG He. Design and in vivo evaluation of an indapamide transdermal patch. Int J Pharm, 2009, 370: 129-135. (通讯作者)

[65]LG Zhao, L Fang, YN Xu, S Liu, ZG He, YY Zhao. Transdermal delivery of penetrants with differing lipophilicities using O-acylmenthol derivatives as penetration enhancers. Eur J Pharm Biopharm, 2008, 69:199–213. (通讯作者)

[66]LG Zhao, L Fang, YN Xu, YY Zhao, ZG He. Effect of O-acylmenthol on transdermal delivery of drugs with different lipophilicity. Int J Pharm, 2008, 352: 92–103. (通讯作者)

[67] CS Ren, L Fang, T Li, ML Wang, LG Zhao, ZG He. Effect of permeation enhancers and organic acids on the skin permeation of indapamide. Int J Pharm, 2008, 350: 43–47. (通讯作者)

[68] ML Wang, L Fang, CS Ren, T Li. Effect of ion-pairing and enhancers on scutellarin skin permeability. J Pharm Pharmacol, 2008, 60: 425–435. (通讯作者)

[69] YX Jiang, L Fang, XC Niu, R Ma, ZG He. The effect of ion pairing on the skin permeation of amlodipine. Die pharmazie, 2008, 63(5): 356-360. (通讯作者)

[70]R Ma, L Fang, XC Niu, YX Jiang, ZG He. Effect of ion-pairing on the permeation of glibenclamide through rat skin. J Drug Deliv Sci Tech, 2008, 18(4): 279-284. (通讯作者)

[71]Y Morimoto, M Mutoh, H Ueda, L Fang, K Hirayama, M Atobe, D Kobayashi. Elucidation of the transport pathway enhanced by low-frequency sonophoresis using hydrodynamic pore theory and confocal microscopy in hairless rat skin. J Control Release, 2005, 103: 587–597.

[72]L Fang, S Numajiri, D Kobayashi, H Ueda, K Nakayama, H Miyamae, Y Morimoto. Physicochemical and crystallographic characterization of mefenamic acid complexes with alkanolamines. J Pharm Sci, 2004, 93: 144–54.

[73] L Fang, S Numajiri, D Kobayashi, Y Morimoto. The use of complexation with alkanolamines to facilitate skin permeation of mefenamic acid. Int J Pharm, 2003, 262: 13–22.

[74]L Fang, Y Kobayashi, S Numajiri, D Kobayashi, Y Morimoto. The enhancing effect of a triethanolamine- ethanol-isoproply myristate mixed system on the skin permeation of acidic drugs. Biol Pharm Bull, 2002, 25: 1339–1344.

[75] S Ohmori, L Fang, M Kawase, S Saito, Y Morimoto. Tolerance to analgesia and dependence liability by topical application of dihydroetorphine to hairless rats. Eur J Pharmacol, 2001, 423: 157–166.

其他：